Homo-BacPROTAC6

Homo-BacPROTAC6 is a ClpC1NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis[1].

C112H164N22O22

2170.63

O=C(N[C@H](C(N(C)[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC1=CN(CC2=CN(CCOCCOCCOCCOCCN3C=C(CN4C=C(C[C@@H]5NC([C@@H](NC([C@@H](N(C)C([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](C[C@@H](C)CO)N(C)C5=O)=O)C)=O)[C@@H](C6=CC=CC=C6)OC)=O)=O)CC(C)C)=O)C(C)C)=O)C7=C4C=CC=C7)N=N3)N=N2)C8=C1C=CC=C8)C9=O)=O)=O)CC(C)C)=O)C(C)C)[C@@H](NC([C@H](C)NC([C@H](C[C@H](CO)C)N9C)=O)=O)[C@H](OC)C%10=CC=CC=C%10

Bacterial; PROTACs

10 mM in DMSO

Room temperature