HSD17B13-IN-48 [CAS 2770246-12-1]

HSD17B13-IN-48 (Compound 12) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-48 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].

[2770246-12-1]

C23H16Cl2FN3O3

472.3

FC1=CC([C@H](C)N2C=NC3=CC=CC(NC(C4=CC(Cl)=C(O)C(Cl)=C4)=O)=C3C2=O)=CC=C1

17β-HSD

10 mM in DMSO

Room temperature