HSD17B13-IN-5

HSD17B13-IN-5 (Compound 96) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with a Ki value of ≤ 50 nM for the estradiol substrate LCMS. HSD17B13-IN-5 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) [1].

C26H15ClF4N4O3S

574.93

N#CC1=CC(C2=NC(C(NCC3=C(C(F)(F)F)C=CC=C3)=O)=C(NC(C4=CC(F)=C(C(Cl)=C4)O)=O)S2)=CC=C1

17β-HSD

10 mM in DMSO

Room temperature