HSD17B13-IN-59 [CAS 2770247-11-3]

HSD17B13-IN-59 (Compound 177) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-59 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].

[2770247-11-3]

C24H17Cl2N5O3

494.33

O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC=CC(N=CN3CC4=NN(C)C5=C4C=CC=C5)=C2C3=O

17β-HSD

10 mM in DMSO

Room temperature