HSD17B13-IN-75 [CAS 2770246-20-1]

HSD17B13-IN-75 (Compound 21) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-75 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].

[2770246-20-1]

C24H16Cl2FN3O3

484.31

OC1=C(Cl)C=C(C(NC2=CC=CC3=C2C(N(C4(CC4)C5=CC=CC=C5F)C=N3)=O)=O)C=C1Cl

17β-HSD

10 mM in DMSO

Room temperature