Hsp70/FoxM1-IN-1

Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1[1].

C21H14BrClN2O3S3

553.9

BrC1=C2N=C(SC2=CC(S(=O)(NC(C3=CC=CC=C3)=O)=O)=C1)SCC4=CC=C(C=C4)Cl

DNA/RNA Synthesis; HSP

HSP70

Room temperature