HSP70-IN-6 [CAS 3048341-44-9]

HSP70-IN-6 (Compound JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction (PPI) (IC50: 70 nM) . HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC50s of 0.43 μM (BV173), 0.88 μM (K562), 0.19 μM (K562-R3) [1].

[3048341-44-9]

C28H30ClN3O2

476.01

OC1=C(C(NCCN2CCCCC2)=CC(C3=CC=C(C=C3)OC4=CC(C)=C(C(C)=C4)Cl)=C1)C#N

Apoptosis; Bcl-2 Family; HSP

Bim; HSP70

Room temperature