HSP70-IN-7

HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs) . HSP70-IN-7 can be used for the study of breast cancer[1].

C55H66BrN4O2PS

958.08

CN(CCNC(C1=C2C3=CC=CC2=C(C=C1)SC4CCCCC4)=C(C3=O)C#N)CCNC(CCCCCCCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O.[Br-]

Apoptosis; HSP

HSP70

Room temperature