Hsp90-Cdc37-IN-4 [CAS 2758818-41-4]

Hsp90-Cdc37-IN-4, a Celastrol derivative, inhibits the Hsp90-Cdc37 protein-protein interaction (PPI). Hsp90-Cdc37-IN-4 selectively inhibits casein kinase 2 (CK2), reducing phosphorylation of its substrate Cdc37 at Serine 13. Hsp90-Cdc37-IN-4 induces G0/G1 cell cycle arrest and triggers apoptosis via the mitochondrial pathway. Hsp90-Cdc37-IN-4 demonstrates potent anti-breast cancer activity[1].

[2758818-41-4]

C40H50N2O5

638.84

O=C1C(O)=C(C)C2=CC=C([C@](CC[C@]3(C)[C@@]4([H])C[C@](C)(C(NCCCOC(/C=C/C5=NC=CC=C5)=O)=O)CC3)(C)[C@@]4(C)CC6)[C@]6(C)C2=C1

Apoptosis; Casein Kinase; HSP

Room temperature