HSP90-IN-13 [CAS 2446055-29-2]

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC50 value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway[1].

[2446055-29-2]

C26H21N5O3S

483.54

O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O

Apoptosis; EGFR; HSP; Topoisomerase; VEGFR

EGFR/ErbB1/HER1; HSP90; Topoisomerase; VEGFR2/KDR/Flk-1

10 mM in DMSO

Room temperature