HSP90-IN-14 [CAS 1995132-67-6]

HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].

[1995132-67-6]

C14H8Cl2N4O4S

399.21

O=C(O)C(NC1=CC=C2N=C(NC(C3=CC(Cl)=C(Cl)N3)=O)SC2=C1)=O

HSP; Influenza Virus

HSP90

10 mM in DMSO

Room temperature