HSP90-IN-33

HSP90-IN-33 (compound 24e) is a potent Hsp90 inhibitor with Kd values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt[1].

C21H25Cl2N5O2

450.36

O=C(C1=C(Cl)C(Cl)=C(C)N1)NC2=CC=C(C(N)=O)C=C2N3CC4(CN(C)CC4)CC3

Apoptosis; HSP

HSP90

Room temperature