HTH-01-091 [CAS 2000209-42-5]

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1].

[2000209-42-5]

C26H28Cl2N4O2

499.43

O=C1N([C@H]2CC[C@H](CN(C)C)CC2)C3=C(CN1)C=NC4=CC=C(C5=CC(Cl)=C(O)C(Cl)=C5)C=C34

CDK; DYRK; GSK-3; MELK; mTOR; Pim; RIP kinase

CDK7; DYRK4; mTOR; PIM1; PIM2; PIM3; RIPK2

98.64

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years (Powder)

Blue Ice