HTS10307 [CAS 81682-91-9]

HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease[1].

[81682-91-9]

C14H8N2O2S

268.29

O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3

AP-1

FosB

Room temperature