Human α-defensin 5

Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16) . Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity[1].

C144H238N50O45S6

3582.13

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]1C(C)C)=O)=O)CO)=O)CC(C)C)=O)CO)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)C)=O)CSSC[C@@H]2NC3=O)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC(C)C)=O)CCCNC(N)=N)=O)CC4=CC=C(O)C=C4)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)CO)=O)[C@H](CC)C)=O)CCC(O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CSSC[C@H](NC2=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O

HPV; Parasite

10 mM in DMSO

Room temperature