HuR degrader 2 [CAS 3040301-46-7]

HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio [1].

[3040301-46-7]

C20H15N3O3

345.35

O=C1NC(C(C2=COC3=C2C=CC(C4=C(C=CN5)C5=NC=C4)=C3)CC1)=O

HuR; Molecular Glues

10mM

98.47

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature