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Hydroxy desmethyl Bosentan [CAS 253688-62-9]
Hydroxy desmethyl Bosentan [CAS 253688-62-9]
SKU:QM-0062678-01
£381.69 GBP
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Product Details
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Description
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].
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CAS Number
[253688-62-9]
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Molecular Formula
C26H27N5O7S
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Molecular Weight
553.59
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Smiles
O=S(C1=CC=C(C(C)(C)CO)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4O)=O
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Target
Drug Metabolite
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302
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Precautions
P264-P270-P330-P501
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Hydroxy desmethyl Bosentan [CAS 253688-62-9]
Hydroxy desmethyl Bosentan is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.