Hypoxia inducer-1

Hypoxia inducer-1 (Compound N6) is an orally active hypoxia activated nitric oxide (NO) donor compound. Hypoxia inducer-1 exhibits highly selective NO release under hypoxic conditions and inhibits hypoxia-induced apoptosis, necrosis, and the increase in ROS levels. Hypoxia inducer-1 regulates vascular dilation and has a protective effect in a mouse model of myocardial hypoxia injury. Hypoxia inducer-1 can be used in the research of coronary heart disease[1].

C14H12FN3O4

305.26

CN(C1=CC=C(OCC2=CC(F)=C(C=C2)[N+]([O-])=O)C=C1)N=O

Apoptosis; Reactive Oxygen Species (ROS)

Room temperature