I-138 [CAS 2098211-50-6]

I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323. I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells[1].

[2098211-50-6]

C26H23F3N6O

492.5

O=C1NC2=CN=C(C3=CC=CC=C3C(C)C)N=C2N1CC4=CC=C(C5=NC(C(F)(F)F)=CN5C)C=C4

Deubiquitinase

10mM

99.75

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature