I-As-1

I-As-1 is a potent inhibitor of Bruton’s tyrosine kinase (BTK), with the IC50 of 2.35 nM. I-As-1 shows antiproliferative activities among Ramos cells and OCI-LY10 cells with IC50s of 0.52 μM and 0.11 μM, respectively[1].

C26H27AsN6O2S2

594.58

O=C(C[As]1SCCS1)N2CCC[C@@H](N3C4=NC=NC(N)=C4C(C5=CC=C(C=C5)OC6=CC=CC=C6)=N3)C2

Btk

10 mM in DMSO

Room temperature