I1421

I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor to enhance CFTR currents[1].

C18H18FN3O3

343.35

O=C(N1N=C(N)C2=C1C=C(CO)C=C2)[C@@H](C)COC3=CC=C(F)C=C3

CFTR

99.15

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature