IACS-8779 (disodium) [CAS 2243079-27-6]

IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma[1].

[2243079-27-6]

C21H23N9Na2O10P2S2

733.52

NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@H]4[C@H]([C@H]3O[P@@](OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C7=C(C=C6)C(N)=NC=N7)O)O[P@@](OC4)(S[Na])=O)(S[Na])=O)O

STING

10 mM in DMSO

Room temperature