ICI 216140 [CAS 124001-41-8]

ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC50 of 2 nM. ICI 216140 can reduce Bombesin -stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195) -stimulated increases in blood pressure[1][2].

[124001-41-8]

C45H65N13O8

916.08

O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C)C(N[C@H](C(N[C@@H](CC(C)C)C(NC)=O)=O)CC1=CN=CN1)=O)=O)=O)[C@@H](NC([C@@H](NC(C(C)C)=O)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34

Bombesin Receptor

99.78

DMSO : 50 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice