ID11916 [CAS 2785317-21-5]

ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3[1].

[2785317-21-5]

C29H27F3N8O3S

624.64

O=C1C(C)(N(C(N1C2=CN=C(C(C(F)(F)F)=C2)C#N)=S)C3=CC=C(C(C4=NN5C(C(N4)=O)=C(N=C5CCC)C)=C3)OCC)C

Androgen Receptor; Phosphodiesterase (PDE)

PDE5

Room temperature