IDO1/TDO-IN-1 [CAS 2379527-72-5]

IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

[2379527-72-5]

C21H16O6

364.35

CC(OCC1=COC2=C1C(C(C3=C2C=CC4=C3C=CC(C4(C)C)=O)=O)=O)=O

Apoptosis; Bcl-2 Family; Indoleamine 2,3-Dioxygenase (IDO)

IDO1

10 mM in DMSO

Room temperature