IDO1/TDO-IN-7

IDO1/TDO-IN-7 (Compound 43b), an isoquinoline derivative, is a potent dual IDO1/TDO inhibitor, with IC50s of 0.31 μM and 0.08 μM, respectively. IDO1/TDO-IN-7 displays acceptable pharmacokinetic profiles and potent antitumor efficacy with low toxicity in B16-F10 tumor model[1].

C17H13F3N2O4S

398.36

OC1=C2C(C=C(C3=CC=C(NS(=O)(C(F)(F)F)=O)C=C3)N=C2)=CC=C1OC

Indoleamine 2,3-Dioxygenase (IDO)

Room temperature