IDO1/TDO-IN-8 [CAS 3085413-22-2]

IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression[1].

[3085413-22-2]

C17H14N2S

278.37

CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1

Indoleamine 2,3-Dioxygenase (IDO)

IDO1

Room temperature