IDOR-1104-0086 is an orally active Kv7 potassium channel opener with an EC50 of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy[1].
CAS Number
[2756581-81-2]
Molecular Formula
C15H15F5N2O
Molecular Weight
334.28
Smiles
O=C(NCC1=CC=CC(C(F)(F)F)=C1)NC2(C3)CC3(C(F)F)C2
Target
Potassium Channel
Isoform
Voltage-gated potassium channel
Purity
98.98
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)