IL-6-IN-2 [CAS 296790-70-0]

IL-6-IN-2 (Compound 15) is an inhibitor of the IL-6/IL-6R protein interaction. The ∆G binding energy of IL-6-IN-2 is −36.50 kcal/mol. Contributions of Lys66, Phe74, Gln175, Ser176, and Arg179 to IL-6 binding are −1.10, −8.68, −6.91, −3.69, and −1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption[1].

[296790-70-0]

C26H24N4O3

440.49

OC1=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=CC=C(C)O4)C(C)=NN1C5=CC=CC=C5

Interleukin Related

99.95

DMSO : 25 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature