Ilginatinib (maleate) [CAS 1354799-87-3]

Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM) .

[1354799-87-3]

C25H24FN7O4

505.5

CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1.O=C(O)/C=C\C(O)=O

JAK

JAK1; JAK2; JAK3; Tyk2

99.87

DMSO : ≥ 30 mg/mL|H2O : < 0.1 mg/mL

4°C (Powder, sealed storage, away from moisture)

Room Temperature