INF200

INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD) -induced metaflammation, and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles, and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP) . INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation[1].

C13H13ClN2O4

296.71

ClC1=CC=CC=C1CC(O2)=NN(CC(OCC)=O)C2=O

NOD-like Receptor (NLR) ; Pyroptosis

10 mM in DMSO

Room temperature