INNO-220 [CAS 3032576-92-1]

INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1].

[3032576-92-1]

C23H20N4O3

400.43

CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5

Casein Kinase; MALT1; MDM-2/p53; Molecular Glues

98.6

DMSO : 2.5 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice