IOX5

IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC50 of 0.19 μM for PHD2. IOX5 stabilizes HIF-1α in acute myeloid leukemia (AML) cells, inhibits cell proliferation and induces apoptosis. IOX5 has anti-leukemia activity[1].

C17H19F3N4O2

368.35

FC(F)([C@H]1CC[C@H](CNC(C2=CNC(N3N=CC=C3)=CC2=O)=O)CC1)F

Apoptosis; HIF/HIF Prolyl-Hydroxylase

99.39

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature