IRE1α kinase-IN-1 [CAS 2328097-41-0]
IRE1α kinase-IN-1 [CAS 2328097-41-0]
SKU:QM-0145715-01
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Product Details
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Description
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM) [1].
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CAS Number
[2328097-41-0]
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Molecular Formula
C26H26ClFN8
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Molecular Weight
504.99
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Smiles
CN1CCC(CNC2=CC(Cl)=NN3C2=NC=C3C4=C(F)C=C5C(N=C(NC6=CC=CC=C6)N5)=C4)CC1
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Target
IRE1
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Purity
98.94
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Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301, H311, H331
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Precautions
H301, H311, H331
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IRE1α kinase-IN-1 [CAS 2328097-41-0]
IRE1α kinase-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.