ISAM-CG557
ISAM-CG557
SKU:QM-0013333
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Product Details
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Description
ISAM-CG557 is a selective CB2R agonist, with a Ki of 54.6 nM. ISAM-CG557 reduces intracellular ROS levels and caspase activity. ISAM-CG557 exhibits significant MAPK bias and moderate G-protein bias, with CB2R EC50s of 0.60 nM (cAMP), 60.9 nM (β-arrestin) and 0.03 nM (MAPK) . ISAM-CG557 exerts potent anti-inflammatory effects by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines in cells. ISAM-CG557 can be used for the study of neuroinflammatory and neurodegenerative disorders[1].
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Molecular Formula
C21H21FN4O2
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Molecular Weight
380.42
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Smiles
O=C([C@H]1N(C(C2=NN(CC3=CC=C(F)C=C3)C4=C2C=CC=C4)=O)CCCC1)N
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Target
Arrestin; Cannabinoid Receptor; Caspase; p38 MAPK; Reactive Oxygen Species (ROS)
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Isoform
CB2
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Shipping Conditions
Room temperature
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ISAM-CG557
ISAM-CG557 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.