Ischemin (sodium)

Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia) [1].

C15H16N3NaO4S

357.36

CC1=CC(/N=N/C2=C(C=C(C(S(=O)(O[Na])=O)=C2)C)C)=C(C=C1O)N

Apoptosis; Epigenetic Reader Domain; MDM-2/p53

99.32

H2O : 25 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature