ISX-9 (GMP) [CAS 832115-62-5]
ISX-9 (GMP) [CAS 832115-62-5]
SKU:QM-0060348-01
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Product Details
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Description
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1][2][3]. In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression[1]. Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2) [1]. In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2[1].
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CAS Number
[832115-62-5]
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Molecular Formula
C11H10N2O2S
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Molecular Weight
234.27
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Smiles
O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
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Target
Calcium Channel
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Purity
99.5
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Solubility
10 mM in DMSO
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Storage Conditions
Keep sealed and protect from light, store at 2-8°C
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Shipping Conditions
Blue Ice
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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ISX-9 (GMP) [CAS 832115-62-5]
ISX-9 (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.