IT-901 [CAS 1584121-99-2]

IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC50 of 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD) [1][2].

[1584121-99-2]

C17H14N2O4S

342.37

O=C(/C(C(N1)=O)=C\C2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S

NF-κB

C-Rel; NF-κB

99.32

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years (Powder)

Blue Ice