(+) -ITD-1 [CAS 1409968-46-2]

(+) -ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+) -ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs) [1].

[1409968-46-2]

C27H29NO3

415.52

O=C(C([C@H](C1=CC=C(C2=CC=CC=C2)C=C1)C(C(C3)=O)=C(CC3(C)C)N4)=C4C)OCC

TGF-beta/Smad; TGF-β Receptor

Room temperature