Itraconazole-d5 [CAS 1217510-38-7]

Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

[1217510-38-7]

C35H33D5Cl2N8O4

710.66

ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)C([2H])([2H])C([2H])([2H])[2H])C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7

Antibiotic; Autophagy; Cytochrome P450; Fungal; Hedgehog

99.55

DMF : ≥ 0.5mg/mL|DMSO : ≥ 0.5mg/mL

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335