IV-255

IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide[1].

C19H19F2N3O2

359.37

COC1=CC=C(N2[C@H]3CN([C@@H](C2)C3)C(NC4=CC(F)=C(C=C4)F)=O)C=C1

Epigenetic Reader Domain

98.41

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature