Ivabradine [CAS 155974-00-8]

Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If) . Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

[155974-00-8]

C27H36N2O5

468.59

O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1

HCN Channel

99.93

10 mM in DMSO

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature