Ivacaftor-d4

Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor. Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[1].

C24H24D4N2O3

396.52

O=C(C1=CNC2=C(C1=O)C([2H])=C([2H])C([2H])=C2[2H])NC3=CC(O)=C(C(C)(C)C)C=C3C(C)(C)C

CFTR

97.32

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335