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Ivarmacitinib (sulfate) [CAS 1639419-51-4]
Ivarmacitinib (sulfate) [CAS 1639419-51-4]
SKU:QM-0058571
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Product Details
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Description
Ivarmacitinib (SHR0302) sulfate is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of Ivarmacitinib for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. Ivarmacitinib inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. Ivarmacitinib has anti-proliferative and anti-inflammatory effects[1][2].
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CAS Number
[1639419-51-4]
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Molecular Formula
C18H24N8O6S2
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Molecular Weight
512.56
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Smiles
O=C(N1C[C@@]2([H])[C@@](C[C@H](N(C)C3=C4C(NC=C4)=NC=N3)C2)([H])C1)NC5=NC(OC)=NS5.O=S(O)(O)=O
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Target
Apoptosis; JAK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Ivarmacitinib (sulfate) [CAS 1639419-51-4]
Ivarmacitinib (sulfate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.