IWR-1 (GMP) [CAS 1127442-82-3]
IWR-1 (GMP) [CAS 1127442-82-3]
SKU:QM-0004830
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Product Details
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Description
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis[1][2][4].
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CAS Number
[1127442-82-3]
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Molecular Formula
C25H19N3O3
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Molecular Weight
409.44
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Smiles
O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([C@]4([H])[C@](C5)([H])C=C[C@]5([H])[C@]64[H])=O)C6=O)C=C3
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Target
Organoid; Wnt
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Shipping Conditions
Room temperature
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IWR-1 (GMP) [CAS 1127442-82-3]
IWR-1 (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.