J-115814 [CAS 329716-61-2]

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].

[329716-61-2]

C29H38ClN5O3S

572.16

CC1=C(SC(CCC2=CC(N3CCOCC3)=CC(NC(C)C4=CC(NC(OC(C)C)=O)=CC(Cl)=C4)=N2)=N1)CC

Neuropeptide Y Receptor

NPY Y1 receptor; NPY Y2 receptor; NPY Y4 receptor; NPY Y5 receptor

Room temperature