Jaspamycin [CAS 22242-96-2]

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

[22242-96-2]

C12H12N4O5

292.25

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2C#N)N=CN1

Parasite; PKA

PKA; PKAR; Trypanosoma

98.94

DMSO : 41.67 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature