JBSNF-000028 (free base) [CAS 3026599-90-3]

JBSNF-00002 free base is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 free base can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 free base exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 free base can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease[1].

[3026599-90-3]

C11H13N3

187.24

CN1CC2=C3C(CCN3C1=N)=CC=C2

Amine N-methyltransferase

99.2

DMSO : 60 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature