Name: JGB1741 [CAS 1256375-38-8]
Brand: QuantiMol
SKU: QM-0136993-01
Price: 103.75 GBP
Availability: InStock

Product Details

Description
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ～15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research[1].
CAS Number
[1256375-38-8]
Molecular Formula
C27H24N2O2S
Molecular Weight
440.56
Smiles
OC1=C(C2=C(C=C1)C=CC=C2)/C=N/C3=C(C4=C(S3)CCCC4)C(NCC5=CC=CC=C5)=O
Target
Apoptosis; Sirtuin
Isoform
SIRT1; SIRT2; SIRT3
Purity
99.37
Solubility
DMSO : 5 mg/mL (ultrasonic)
Storage Conditions
4°C (Powder, protect from light)
Shipping Conditions
Room Temperature

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Variant	Variant total	Quantity	Price	Variant total
1 mgQM-0136993-01	1 mgQM-0136993-01 £103.75/ea	£0.00	Quantity	£103.75/ea	£0.00

5 mgQM-0136993-02	5 mgQM-0136993-02 £325.81/ea	£0.00	Quantity	£325.81/ea	£0.00

10 mgQM-0136993-03	10 mgQM-0136993-03 £520.20/ea	£0.00	Quantity	£520.20/ea	£0.00

25 mgQM-0136993-04	25 mgQM-0136993-04 £991.63/ea	£0.00	Quantity	£991.63/ea	£0.00

50 mgQM-0136993-05	50 mgQM-0136993-05 £1,556.60/ea	£0.00	Quantity	£1,556.60/ea	£0.00

100 mgQM-0136993-06	100 mgQM-0136993-06 £2,435.05/ea	£0.00	Quantity	£2,435.05/ea	£0.00

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JGB1741 [CAS 1256375-38-8]

JGB1741 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.