JH-VIII-49 [CAS 2209084-73-9]

JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02[2].

[2209084-73-9]

C30H40N2

428.65

C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1

CDK; Ligands for Target Protein for PROTAC

CDK8

Room temperature

H315-H319-H320

P264-P280-P302+P352-P305+P351+P338-P362